Unlocking efficiency in column chromatography with packed bed supporting inserts
To purify increasing amounts of biotherapeutics more efficiently, the use of high flow rates or greater resin bed heights during downstream chromatography steps is a tantalizing option. A limitation of utilizing high flow rates is the differential pressure generated by packed chromatography resin be...
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| Main Authors: | Romone M. Fancy, David H. Abraham, Matthew R. Taylor, Cole McMullin, Nicholas S. Brann, Daniel M. Bailey, David I. Brown, Heather Bethea Horne, Leslie S. Wolfe |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-06-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2025.1613174/full |
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