Unlocking efficiency in column chromatography with packed bed supporting inserts

Unlocking efficiency in column chromatography with packed bed supporting inserts

To purify increasing amounts of biotherapeutics more efficiently, the use of high flow rates or greater resin bed heights during downstream chromatography steps is a tantalizing option. A limitation of utilizing high flow rates is the differential pressure generated by packed chromatography resin be...

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Bibliographic Details
Main Authors: Romone M. Fancy, David H. Abraham, Matthew R. Taylor, Cole McMullin, Nicholas S. Brann, Daniel M. Bailey, David I. Brown, Heather Bethea Horne, Leslie S. Wolfe
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
resin bed
chromatography
biomanufacturing
antibody
purification
permeability
Online Access:https://www.frontiersin.org/articles/10.3389/fbioe.2025.1613174/full
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https://www.frontiersin.org/articles/10.3389/fbioe.2025.1613174/full

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