Polymeric Nanoparticles Potentiate the Anticancer Activity of Novel PI3Kα Inhibitors Against Triple-Negative Breast Cancer Cells

Polymeric Nanoparticles Potentiate the Anticancer Activity of Novel PI3Kα Inhibitors Against Triple-Negative Breast Cancer Cells

<b>Background</b>: Dysregulation in phosphoinositide-3-kinase alpha (PI3Kα) signaling is implicated in the development of various cancers, including triple-negative breast cancer (TNBC). We have previously synthesized a series of N-phenyl-6-chloro-4-hydroxy-2-quinolone-3-carboxamides as...

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Bibliographic Details
Main Authors: Suhair Sunoqrot, Samah Abusulieh, Dima Sabbah
Format: Article
Language:English
Published: MDPI AG 2024-11-01
Series:Biomedicines
Subjects:
PI3Kα
polymeric nanoparticles
protein kinases
TPGS
triple-negative breast cancer
Online Access:https://www.mdpi.com/2227-9059/12/12/2676
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