Loss of OBSCN expression promotes bladder cancer progression but enhances the efficacy of PD-L1 inhibitors

Loss of OBSCN expression promotes bladder cancer progression but enhances the efficacy of PD-L1 inhibitors

Abstract Background As the objective overall response rate to immune checkpoint inhibitors (ICIs) is less than 30% in late stage or metastatic bladder cancer (BLCA), elucidating the intrinsic mechanisms of immune evasion is of great importance for the discovery of predictive and prognostic biomarker...

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Main Authors: Tao Wang, Tuanjie Guo, Juanjuan Sun, Xinyue Zang, Lei Dong, Jian Zhang, Siteng Chen, Guihua Chen, Sicong Ma, Xinyu Zhai, Chuanmin Chu, Chaofu Wang, Xiang Wang, Dongliang Xu, Mingyue Tan
Format: Article
Language:English
Published: BMC 2025-03-01
Series:Cell & Bioscience
Subjects:
Bladder cancer
Immunotherapy
Immune checkpoint inhibitor
OBSCN
Obscurin
Online Access:https://doi.org/10.1186/s13578-025-01379-w
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https://doi.org/10.1186/s13578-025-01379-w

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