Deglycosylated azithromycin alleviates cisplatin-evoked constipation in mice by altering host metabolome and gut microbiota composition

Deglycosylated azithromycin alleviates cisplatin-evoked constipation in mice by altering host metabolome and gut microbiota composition

IntroductionChemotherapy induced constipation (CIC) is a gastrointestinal side effect that occurs in patients receiving chemotherapy, which can further deteriorate the living quality of cancer patients. Deglycosylated azithromycin (Deg-AZM), a newly developed Class I drug with good therapeutic effec...

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Bibliographic Details
Main Authors: Xiaoting Gu, Shuwen Zhu, Weixue Tian, Xiaohe Li, Yutian Cai, Chaoyue Zheng, Xiang Xu, Conglu Zhao, Hongting Liu, Yao Sun, Zhilin Luo, Honggang Zhou, Xiaoyu Ai, Cheng Yang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Microbiology
Subjects:
Deg-AZM
pharmacodynamic
16S rRNA
untargeted metabolomics
gut microbiota
intestinal motility
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2025.1437662/full
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https://www.frontiersin.org/articles/10.3389/fmicb.2025.1437662/full

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