Unraveling the molecular mechanisms of paclitaxel in high-grade serous ovarian cancer through network pharmacology

Unraveling the molecular mechanisms of paclitaxel in high-grade serous ovarian cancer through network pharmacology

Abstract High-grade serous ovarian cancer (HGSOC) is the most common and aggressive subtype of epithelial ovarian cancer, often diagnosed at advanced stages with a poor prognosis. Paclitaxel (PTX), a standard chemotherapeutic agent for HGSOC, exerts cytotoxic effects on cancer cells and modulates th...

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Bibliographic Details
Main Authors: Yihao Pei, Ziqi Yang, Ben Li, Xiping Chen, Yiming Mao, Yun Ding
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Scientific Reports
Subjects:
Paclitaxel
High-grade serous ovarian cancer
Bioinformatics
Network pharmacology
Molecular docking
Diagnostic model
Online Access:https://doi.org/10.1038/s41598-025-00658-3
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https://doi.org/10.1038/s41598-025-00658-3

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