Ultrasound nanodroplets loaded with Siglec-G siRNA and Fe3O4 activate macrophages and enhance phagocytosis for immunotherapy of triple-negative breast cancer

Ultrasound nanodroplets loaded with Siglec-G siRNA and Fe3O4 activate macrophages and enhance phagocytosis for immunotherapy of triple-negative breast cancer

Abstract Background The progression of triple-negative breast cancer is shaped by both tumor cells and the surrounding tumor microenvironment (TME). Within the TME, tumor-associated macrophages (TAMs) represent a significant cell population and have emerged as a primary target for cancer therapy. As...

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Bibliographic Details
Main Authors: Ci Yin, Guojuan Wang, Qin Zhang, Zhendong Li, Tiantian Dong, Qi Li, Nianhong Wu, Yaqin Hu, Haitao Ran, Pan Li, Yang Cao, Fang Nie
Format: Article
Language:English
Published: BMC 2024-12-01
Series:Journal of Nanobiotechnology
Subjects:
Triple-negative breast cancer
Macrophages
CD24/Siglec-G
Fe3O4
Immunotherapy
Online Access:https://doi.org/10.1186/s12951-024-03051-w
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https://doi.org/10.1186/s12951-024-03051-w

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