Periodontitis aggravates pulmonary fibrosis by Porphyromonas gingivalis-promoted infiltration of neutrophils and Th17 cells

Periodontitis aggravates pulmonary fibrosis by Porphyromonas gingivalis-promoted infiltration of neutrophils and Th17 cells

IntroductionIdiopathic pulmonary fibrosis (IPF) is a fatal interstitial lung disease. However, the pathogeny of IPF is poorly understood, and therapeutic options are very limited. Periodontitis (PD) is a chronic inflammatory disease that leads to dysbiosis of both the oral microbiome and host immune...

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Main Authors: Hui-Lin Ye, Xiao-Qian Meng, Huxiao Li, Xiaoli Sun, Wen-Zhen Lin, Lu-Jun Zhou, Jun Zhang, Chenchen Hou, Shuo Xu, Bo-Yan Chen, Che Qiu, Yu-Lin Li, Yong-Li Wang, Li-Feng Yan, Sheng-Zhong Duan
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
periodontitis
idiopathic pulmonary fibrosis
Porphyromonas gingivalis
neutrophils
Th17 cells
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2025.1595500/full
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https://www.frontiersin.org/articles/10.3389/fcimb.2025.1595500/full

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