Treatment Response to Oncolytic Virus in Patient-Derived Breast Cancer and Hypopharyngeal Cancer Organoids: Evaluation via a Microfluidics Organ-on-a-Chip System

Treatment Response to Oncolytic Virus in Patient-Derived Breast Cancer and Hypopharyngeal Cancer Organoids: Evaluation via a Microfluidics Organ-on-a-Chip System

In this study, we present an oncolytic virus (OV) evaluation system established using microfluidic organ-on-a-chip (OOC) systems and patient-derived organoids (PDOs), which was used in the development of a novel oncolytic virus, AD4-GHPE. An OV offers advantages such as good targeting ability and mi...

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Bibliographic Details
Main Authors: Yu Sun, Jiaqi Liu, Li Zhu, Fang Huang, Yanbo Dong, Shuang Liu, Siyi Chen, Wei Ji, Jingjing Lu, Liangfa Liu, Shanhu Li
Format: Article
Language:English
Published: MDPI AG 2025-02-01
Series:Bioengineering
Subjects:
oncolytic virus
patient-derived organoids
breast cancer
head and neck tumors
microfluidics
organ-on-a-chip
Online Access:https://www.mdpi.com/2306-5354/12/2/146
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