Differential expression of CD175 and CA19-9 in pancreatic adenocarcinoma

Differential expression of CD175 and CA19-9 in pancreatic adenocarcinoma

Abstract Alterations in protein glycosylation are observed in many solid tumor types leading to formation of tumor-associated carbohydrate antigens (TACAs). The most common TACA is the Tn antigen (CD175), which is a mucin-type O-GalNAc-Ser/Thr/Tyr glycan in membrane and secreted glycoproteins. In ad...

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Bibliographic Details
Main Authors: Jane J. Cheng, Yasuyuki Matsumoto, Gabrielle E. Dombek, Kathryn A. Stackhouse, Ana Sofia Ore, Jonathan N. Glickman, Jamie Heimburg-Molinaro, Richard D. Cummings
Format: Article
Language:English
Published: Nature Portfolio 2025-02-01
Series:Scientific Reports
Subjects:
Tumor-associated carbohydrate antigens (TACAs)
CD175
Sialyl-Lewis a (CA19-9)
CA19-9
Sialyl-Lewis x (CD15s)
Pancreatic ductal adenocarcinoma (PDAC)
Online Access:https://doi.org/10.1038/s41598-025-86988-8
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https://doi.org/10.1038/s41598-025-86988-8

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