Reduced removal of waste products from energy metabolism takes center stage in human brain aging

Reduced removal of waste products from energy metabolism takes center stage in human brain aging

Abstract Despite extensive research on neuroimaging correlates of human brain aging, there is little mechanistic insight into how they are linked to loss of brain function. Previous studies on the role of cerebral blood flow (CBF) in supporting brain function have focused on delivery of nutrients, n...

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Main Authors: Silvia Mangia, Mauro DiNuzzo, Sara Ponticorvo, Gerald A. Dienel, Kevin L. Behar, Helene Benveniste, Fahmeed Hyder, Federico Giove, Suzana Herculano-Houzel, Ognen A. Petroff, Lynn E. Eberly, Pavel Filip, Shalom Michaeli, Douglas L. Rothman
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-025-90342-3
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https://doi.org/10.1038/s41598-025-90342-3

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