Perinatal SSRI exposure impacts innate fear circuit activation and behavior in mice and humans

Perinatal SSRI exposure impacts innate fear circuit activation and behavior in mice and humans

Abstract Before assuming its role in the mature brain, serotonin modulates early brain development across phylogenetically diverse species. In mice and humans, early-life SSRI exposure alters the offspring’s brain structure and is associated with anxiety and depression-related behaviors beginning in...

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Main Authors: Giulia Zanni, Milenna T. van Dijk, Martha Caffrey Cagliostro, Pradyumna Sepulveda, Nicolò Pini, Ariel L. Rose, Alexander L. Kesin, Claudia Lugo-Candelas, Priscila Dib Goncalves, Alexandra S. MacKay, Kiyohito Iigaya, Praveen Kulkarni, Craig F. Ferris, Myrna M. Weissman, Ardesheer Talati, Mark S. Ansorge, Jay A. Gingrich
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-58785-4
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https://doi.org/10.1038/s41467-025-58785-4

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