Novel De Novo Intronic Variant of SYNGAP1 Associated With the Neurodevelopmental Disorders

ABSTRACT Background SYNGAP1 encodes a Ras/Rap GTPase‐activating protein that is predominantly expressed in the brain with the functional roles in regulating synaptic plasticity, spine morphogenesis, and cognition function. Pathogenic variants in SYNGAP1 have been associated with a spectrum of neurod...

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Bibliographic Details
Main Authors: Wuming Xie, Baoqiong Liao, Mei Shuai, Rutian Liu, Min Hong, Shuwen He
Format: Article
Language:English
Published: Wiley 2025-02-01
Series:Molecular Genetics & Genomic Medicine
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Online Access:https://doi.org/10.1002/mgg3.70066
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