Solid-phase synthesis and cytotoxic evaluation of novel pyridinium bromides

Solid-phase synthesis and cytotoxic evaluation of novel pyridinium bromides

Abstract A series of amide-based mono and dimeric pyridinium bromides were synthesized using conventional and microwave-assisted solvent-free methods. The quaternization reactions of m-xylene dibromide and 4-nitrobenzylbromide with amide-based substituted pyridine proceeded efficiently, whereas 1,6-...

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Main Authors: Sadaiyan Govindaraj, Kilivelu Ganesan, Perumal Elumalai, Rajanathadurai Jeevitha, Jospin Sindya, Subramani Annadurai, Shiek S. S. J. Ahmed, Mudassar Shahid
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:Scientific Reports
Subjects:
Amide-based pyridinium
Solvent free reaction
Atom economy
Cytotoxic
Molecular docking
BOILED-Egg plot
Online Access:https://doi.org/10.1038/s41598-025-92672-8
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https://doi.org/10.1038/s41598-025-92672-8

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