Optimizing PBMC Cryopreservation and Utilization for ImmunoSpot<sup>®</sup> Analysis of Antigen-Specific Memory B Cells

Optimizing PBMC Cryopreservation and Utilization for ImmunoSpot<sup>®</sup> Analysis of Antigen-Specific Memory B Cells

<b>Background:</b> Measuring frequencies of antigen-specific memory B cells (B<sub>mem</sub>), their immunoglobulin (Ig) class and subclass usage, cross-reactivity, and affinity can provide insights into the efficacy of future antibody responses in case of antigen re-encounte...

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Bibliographic Details
Main Authors: Noémi Becza, Lingling Yao, Paul V. Lehmann, Greg A. Kirchenbaum
Format: Article
Language:English
Published: MDPI AG 2025-07-01
Series:Vaccines
Subjects:
ELISPOT
FluoroSpot
immunological memory
humoral
plasma cell
immune monitoring
Online Access:https://www.mdpi.com/2076-393X/13/7/765
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