Lithium-induced nephrogenic diabetes insipidus following improved medication compliance: a case report
Abstract Background Nephrogenic diabetes insipidus is a rare, often underrecognized complication of long-term lithium therapy. Lithium-induced nephrogenic diabetes insipidus results from chronic renal exposure, leading to significant polyuria, dehydration, and hypernatremia. Case presentation We des...
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| Language: | English |
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BMC
2025-01-01
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| Series: | Journal of Medical Case Reports |
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| Online Access: | https://doi.org/10.1186/s13256-025-05034-3 |
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| author | Eugene Annor Ishita Bhattacharya Mary Bass Emily M. Horvath |
| author_facet | Eugene Annor Ishita Bhattacharya Mary Bass Emily M. Horvath |
| author_sort | Eugene Annor |
| collection | DOAJ |
| description | Abstract Background Nephrogenic diabetes insipidus is a rare, often underrecognized complication of long-term lithium therapy. Lithium-induced nephrogenic diabetes insipidus results from chronic renal exposure, leading to significant polyuria, dehydration, and hypernatremia. Case presentation We describe a case of a 55-year-old White caucasian male with a schizoaffective disorder managed with lithium who presented with altered mental status and electrolyte abnormalities following a recent stroke. Evaluation revealed nephrogenic diabetes insipidus as the primary etiology, likely exacerbated by recent changes in medication adherence. The patient responded well to fluid resuscitation, reduced lithium dosage, and targeted electrolyte management. Conclusion This case underscores the need for vigilance in monitoring patients with nephrogenic diabetes insipidus on chronic lithium therapy, as early recognition and treatment are essential in preventing renal impairment and improving clinical outcomes. |
| format | Article |
| id | doaj-art-5a33507e3c654a24917ca9a204b981a8 |
| institution | Kabale University |
| issn | 1752-1947 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Medical Case Reports |
| spelling | doaj-art-5a33507e3c654a24917ca9a204b981a82025-01-26T12:35:33ZengBMCJournal of Medical Case Reports1752-19472025-01-011911510.1186/s13256-025-05034-3Lithium-induced nephrogenic diabetes insipidus following improved medication compliance: a case reportEugene Annor0Ishita Bhattacharya1Mary Bass2Emily M. Horvath3Department of Internal Medicine, University of Illinois College of MedicineUniversity of Illinois College of MedicineUniversity of Illinois College of MedicineDepartment of Internal Medicine, University of Illinois College of MedicineAbstract Background Nephrogenic diabetes insipidus is a rare, often underrecognized complication of long-term lithium therapy. Lithium-induced nephrogenic diabetes insipidus results from chronic renal exposure, leading to significant polyuria, dehydration, and hypernatremia. Case presentation We describe a case of a 55-year-old White caucasian male with a schizoaffective disorder managed with lithium who presented with altered mental status and electrolyte abnormalities following a recent stroke. Evaluation revealed nephrogenic diabetes insipidus as the primary etiology, likely exacerbated by recent changes in medication adherence. The patient responded well to fluid resuscitation, reduced lithium dosage, and targeted electrolyte management. Conclusion This case underscores the need for vigilance in monitoring patients with nephrogenic diabetes insipidus on chronic lithium therapy, as early recognition and treatment are essential in preventing renal impairment and improving clinical outcomes.https://doi.org/10.1186/s13256-025-05034-3LithiumHypernatremiaPolyuriaDiabetes insipidus |
| spellingShingle | Eugene Annor Ishita Bhattacharya Mary Bass Emily M. Horvath Lithium-induced nephrogenic diabetes insipidus following improved medication compliance: a case report Journal of Medical Case Reports Lithium Hypernatremia Polyuria Diabetes insipidus |
| title | Lithium-induced nephrogenic diabetes insipidus following improved medication compliance: a case report |
| title_full | Lithium-induced nephrogenic diabetes insipidus following improved medication compliance: a case report |
| title_fullStr | Lithium-induced nephrogenic diabetes insipidus following improved medication compliance: a case report |
| title_full_unstemmed | Lithium-induced nephrogenic diabetes insipidus following improved medication compliance: a case report |
| title_short | Lithium-induced nephrogenic diabetes insipidus following improved medication compliance: a case report |
| title_sort | lithium induced nephrogenic diabetes insipidus following improved medication compliance a case report |
| topic | Lithium Hypernatremia Polyuria Diabetes insipidus |
| url | https://doi.org/10.1186/s13256-025-05034-3 |
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