The integrated stress response engages a cell-autonomous, ligand-independent, DR5-driven apoptosis switch
Abstract The integrated stress response (ISR) is a fundamental signaling network that leverages the cell’s biosynthetic capacity against different stresses to restore homeostasis. However, when homeostasis is unattainable, the ISR switches to drive cell death and eliminate irreparably damaged cells....
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2025-02-01
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| Series: | Cell Death and Disease |
| Online Access: | https://doi.org/10.1038/s41419-025-07403-8 |
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