Design, Synthesis, and Biological Activity Evaluation of Novel AZT and Adenosine-Derived 1,2,3-Triazoles

Design, Synthesis, and Biological Activity Evaluation of Novel AZT and Adenosine-Derived 1,2,3-Triazoles

CuSO4/hydrazine hydrate was used as a catalyst system for copper(I)-catalyzed alkyne-azide cycloaddition (CuAAC) of AZT and 5′-azido adenosine with terminal alkynes to give 30 novel 1,2,3-triazole derivatives. Screening for their anticancer, anti-inflammatory, angiotensin-converting enzyme 2 (ACE2),...

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Main Authors: Duc Anh Le, Ngoc Hung Truong, Van Dung Vu, Thanh Huyen Doan, Minh Tri Le, Thi Huong Nguyen, Manh Cuong Nguyen, Huu Nghi Do, Duc Bao Ninh, Phong Le, Thi Phuong Thao Nguyen, Khac Vu Tran, Van Chinh Luu
Format: Article
Language:English
Published: Wiley 2023-01-01
Series:Journal of Chemistry
Online Access:http://dx.doi.org/10.1155/2023/1605316
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http://dx.doi.org/10.1155/2023/1605316

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