scRNA-seq reveals elevated interferon responses and TNF-α signaling via NFkB in monocytes in children with uncomplicated malaria

scRNA-seq reveals elevated interferon responses and TNF-α signaling via NFkB in monocytes in children with uncomplicated malaria

Malaria causes significant morbidity and mortality worldwide, disproportionately impacting sub-Saharan Africa. Disease phenotypes associated with Plasmodium falciparum infection can vary widely, from asymptomatic to life-threatening. To date, prevention efforts, particularly those related to vaccine...

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Main Authors: Collins M. Morang’a, Riley S. Drake, Vincent N. Miao, Nancy K. Nyakoe, Dominic S. Y. Amuzu, Vincent Appiah, Yaw Aniweh, Yaw Bediako, Saikou Y. Bah, Alex K. Shalek, Gordon A. Awandare, Thomas D. Otto, Lucas Amenga-Etego
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Experimental Biology and Medicine
Subjects:
uncomplicated malaria
Plasmodium falciparum
scRNA-Sequencing
immune responses
cell-cell interactions
TNF-α signaling via NFκB
Online Access:https://www.ebm-journal.org/articles/10.3389/ebm.2024.10233/full
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https://www.ebm-journal.org/articles/10.3389/ebm.2024.10233/full

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