Combinatorial discovery of microtopographical landscapes that resist biofilm formation through quorum sensing mediated autolubrication

Combinatorial discovery of microtopographical landscapes that resist biofilm formation through quorum sensing mediated autolubrication

Abstract Bio-instructive materials that intrinsically inhibit biofilm formation have significant anti-biofouling potential in industrial and healthcare settings. Since bacterial surface attachment is sensitive to surface topography, we experimentally surveyed 2176 combinatorially generated shapes em...

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Main Authors: Manuel Romero, Jeni Luckett, Jean-Frédéric Dubern, Grazziela P. Figueredo, Elizabeth Ison, Alessandro M. Carabelli, David J. Scurr, Andrew L. Hook, Lisa Kammerling, Ana C. da Silva, Xuan Xue, Chester Blackburn, Aurélie Carlier, Aliaksei Vasilevich, Phani K. Sudarsanam, Steven Vermeulen, David A. Winkler, Amir M. Ghaemmaghami, Jan de Boer, Morgan R. Alexander, Paul Williams
Format: Article
Language:English
Published: Nature Portfolio 2025-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-60567-x
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https://doi.org/10.1038/s41467-025-60567-x

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