The Occurrence of Sequences Identical with Epitopes from the Allergen Pen a 1.0102 Among Food and Non-Food Proteins
The presence of common epitopes among tropomyosins of invertebrates, including arthropods, e.g. edible ones, may help to explain the molecular basis of cross-reactivity between allergens. The work presented is the first survey concerning global distribution of epitopes from Pen a 1.0102 in universal...
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Institute of Animal Reproduction and Food Research of the Polish Academy of Sciences
2015-03-01
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| Series: | Polish Journal of Food and Nutrition Sciences |
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| Online Access: | http://www.degruyter.com/view/j/pjfns.2015.65.issue-1/pjfns-2015-0002/pjfns-2015-0002.xml?format=INT |
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| author | Minkiewicz Piotr Sokolowska Jolanta Darewicz Malgorzata |
| author_facet | Minkiewicz Piotr Sokolowska Jolanta Darewicz Malgorzata |
| author_sort | Minkiewicz Piotr |
| collection | DOAJ |
| description | The presence of common epitopes among tropomyosins of invertebrates, including arthropods, e.g. edible ones, may help to explain the molecular basis of cross-reactivity between allergens. The work presented is the first survey concerning global distribution of epitopes from Pen a 1.0102 in universal proteome. In the group of known tropomyosin epitopes, the fragment with the sequence ESKIVELEEEL was found in the sequence of channel catfish (Ictalurus punctatus) tropomyosin. To date, this is the first result suggesting the presence of a complete sequential epitope interacting with gE in vertebrate tropomyosin. Another fragment with the sequence VAALNRRIQL, a major part of the epitope, was found in 11 fish, 8 amphibians, 3 birds, 19 mammalians and 4 human tropomyosin sequences. Identical epitopes are common in sequences of invertebrate tropomyosins, including food and non-food allergens annotated in the Allergome database. The rare pentapeptide with the DEERM sequence occurs in proteins not sharing homology with tropomyosins. Pathogenic microorganisms are the most abundant category of organisms synthesizing such proteins. |
| format | Article |
| id | doaj-art-59e56b96f88f4c2b9fde074c7415179e |
| institution | Kabale University |
| issn | 2083-6007 |
| language | English |
| publishDate | 2015-03-01 |
| publisher | Institute of Animal Reproduction and Food Research of the Polish Academy of Sciences |
| record_format | Article |
| series | Polish Journal of Food and Nutrition Sciences |
| spelling | doaj-art-59e56b96f88f4c2b9fde074c7415179e2025-02-02T06:39:00ZengInstitute of Animal Reproduction and Food Research of the Polish Academy of SciencesPolish Journal of Food and Nutrition Sciences2083-60072015-03-01651212910.1515/pjfns-2015-0002pjfns-2015-0002The Occurrence of Sequences Identical with Epitopes from the Allergen Pen a 1.0102 Among Food and Non-Food ProteinsMinkiewicz Piotr0Sokolowska Jolanta1Darewicz Malgorzata2University of Warmia and Mazury in Olsztyn, Department of Food Biochemistry, Plac Cieszyński 1, 10-726 Olsztyn-Kortowo, PolandUniversity of Warmia and Mazury in Olsztyn, Department of Food Biochemistry, Plac Cieszyński 1, 10-726 Olsztyn-Kortowo, PolandUniversity of Warmia and Mazury in Olsztyn, Department of Food Biochemistry, Plac Cieszyński 1, 10-726 Olsztyn-Kortowo, PolandThe presence of common epitopes among tropomyosins of invertebrates, including arthropods, e.g. edible ones, may help to explain the molecular basis of cross-reactivity between allergens. The work presented is the first survey concerning global distribution of epitopes from Pen a 1.0102 in universal proteome. In the group of known tropomyosin epitopes, the fragment with the sequence ESKIVELEEEL was found in the sequence of channel catfish (Ictalurus punctatus) tropomyosin. To date, this is the first result suggesting the presence of a complete sequential epitope interacting with gE in vertebrate tropomyosin. Another fragment with the sequence VAALNRRIQL, a major part of the epitope, was found in 11 fish, 8 amphibians, 3 birds, 19 mammalians and 4 human tropomyosin sequences. Identical epitopes are common in sequences of invertebrate tropomyosins, including food and non-food allergens annotated in the Allergome database. The rare pentapeptide with the DEERM sequence occurs in proteins not sharing homology with tropomyosins. Pathogenic microorganisms are the most abundant category of organisms synthesizing such proteins.http://www.degruyter.com/view/j/pjfns.2015.65.issue-1/pjfns-2015-0002/pjfns-2015-0002.xml?format=INTallergydatabase screeningepitopesIctalurus punctatustropomyosin |
| spellingShingle | Minkiewicz Piotr Sokolowska Jolanta Darewicz Malgorzata The Occurrence of Sequences Identical with Epitopes from the Allergen Pen a 1.0102 Among Food and Non-Food Proteins Polish Journal of Food and Nutrition Sciences allergy database screening epitopes Ictalurus punctatus tropomyosin |
| title | The Occurrence of Sequences Identical with Epitopes from the Allergen Pen a 1.0102 Among Food and Non-Food Proteins |
| title_full | The Occurrence of Sequences Identical with Epitopes from the Allergen Pen a 1.0102 Among Food and Non-Food Proteins |
| title_fullStr | The Occurrence of Sequences Identical with Epitopes from the Allergen Pen a 1.0102 Among Food and Non-Food Proteins |
| title_full_unstemmed | The Occurrence of Sequences Identical with Epitopes from the Allergen Pen a 1.0102 Among Food and Non-Food Proteins |
| title_short | The Occurrence of Sequences Identical with Epitopes from the Allergen Pen a 1.0102 Among Food and Non-Food Proteins |
| title_sort | occurrence of sequences identical with epitopes from the allergen pen a 1 0102 among food and non food proteins |
| topic | allergy database screening epitopes Ictalurus punctatus tropomyosin |
| url | http://www.degruyter.com/view/j/pjfns.2015.65.issue-1/pjfns-2015-0002/pjfns-2015-0002.xml?format=INT |
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