Chromatin interaction-based annotation of regulatory elements reveals dynamic promoter-enhancer interactions in lymphocyte development

Chromatin interaction-based annotation of regulatory elements reveals dynamic promoter-enhancer interactions in lymphocyte development

Summary: Stage- and lineage-specific gene expression patterns are controlled by a complex interplay between transcription factors, the epigenetic landscape, and the three-dimensional (3D) structure of the DNA. The 3D structure allows for the formation of DNA loops that juxtaposition distal regulator...

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Bibliographic Details
Main Authors: Johanna Tingvall-Gustafsson, Christina T. Jensen, Jonas Ungerbäck, Mikael Sigvardsson
Format: Article
Language:English
Published: Elsevier 2025-07-01
Series:iScience
Subjects:
Chromosome organization
Molecular genetics
Epigenetics
Components of the immune system
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004225011162
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