Helicase protein DDX11 as a novel antiviral factor promoting RIG-I-MAVS-mediated signaling pathway

Helicase protein DDX11 as a novel antiviral factor promoting RIG-I-MAVS-mediated signaling pathway

ABSTRACT Type Ι interferon (IFN) production mediated by retinoic acid-inducible gene 1 (RIG-I) and mitochondrial antiviral signaling protein (MAVS) is essential for antiviral innate immune responses. Here, we report the identification of a novel co-sensor for cytosolic nucleic acids: DEAD/H-box heli...

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Main Authors: Jiyu Zhang, Liaoyuan Zhang, Dakai Liu, Hongyan Shi, Xin Zhang, Jianfei Chen, Xiaoman Yang, Miaomiao Zeng, Jialin Zhang, Tingshuai Feng, Xiaoyuan Zhu, Zhaoyang Jing, Zhaoyang Ji, Da Shi, Li Feng
Format: Article
Language:English
Published: American Society for Microbiology 2024-12-01
Series:mBio
Subjects:
DDX11
RIG-I
MAVS
IFN
Online Access:https://journals.asm.org/doi/10.1128/mbio.02028-24
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https://journals.asm.org/doi/10.1128/mbio.02028-24

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