Targeting the major pro-inflammatory interleukin-6-type cytokine receptor gp130 by antagonistic single domain antibodies

Targeting the major pro-inflammatory interleukin-6-type cytokine receptor gp130 by antagonistic single domain antibodies

IntroductionAlthough Interleukin (IL)-6-type cytokine signaling is critical for maintaining the body's homeostasis, aberrant signaling has been observed in numerous diseases including autoimmunity and cancer. Currently, all approved biologics that inhibit IL-6-type cytokines specifically target...

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Main Authors: Silke Pudewell, Julia Heuser, Inna Dorogobed, Britta Lipinski, Thi Hong Hue Tran, Pia Metzenmacher, Richard Kunze, Felix Geyer, Stefan Zielonka, Doreen M. Floss, Harald Kolmar, Jens M. Moll, Jürgen Scheller
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Immunology
Subjects:
IL-6-type cytokines
glycoprotein 130
single domain antibody
inhibitor
inflammation
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1613004/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1613004/full

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