Theoretical investigations on analysis and optimization of freeze drying of pharmaceutical powder using machine learning modeling of temperature distribution

Theoretical investigations on analysis and optimization of freeze drying of pharmaceutical powder using machine learning modeling of temperature distribution

Abstract This study investigates the application of various neural network-based models for predicting temperature distribution in freeze drying process of biopharmaceuticals. For heat-sensitive biopharmaceutical products, freeze drying is preferred to prevent degradation of pharmaceutical compounds...

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Bibliographic Details
Main Authors: Turki Al Hagbani, Jawaher Abdullah Alamoudi, Majed A. Bajaber, Huda Ibrahim Alsayed, Halah Jawad Al-fanhrawi
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Scientific Reports
Subjects:
Freeze drying
Modeling
Biopharmaceuticals
Temperature distribution
Multi-layer Perceptron
Fireworks Algorithm
Online Access:https://doi.org/10.1038/s41598-024-84155-z
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https://doi.org/10.1038/s41598-024-84155-z

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