Mechanistic, in-silico and in vitro studies with nitrofurans reveal potent leishmanicidal activity and inhibition of trypanothione reductase

Mechanistic, in-silico and in vitro studies with nitrofurans reveal potent leishmanicidal activity and inhibition of trypanothione reductase

Visceral leishmaniasis caused by Leishmania infantum and Leishmania donovani is one of the neglected tropical diseases (NTDs) caused by trypanosomatids with treatment options limited to outdated drugs often causing adverse effects and promoting drug resistance. Previous antileishmanial drug discover...

Full description

Saved in:

Bibliographic Details
Main Authors:	Julia Andrés-Rodríguez, María-Cristina González-Montero, Nerea García-Fernández, Juan-José Galano-Frutos, Maria-Cristina de Rosa, Patricia Ferreira, María-Yolanda Pérez-Pertejo, Rosa M. Reguera, Rafael Balaña-Fouce, Carlos García-Estrada
Format:	Article
Language:	English
Published:	Elsevier 2025-08-01
Series:	International Journal for Parasitology: Drugs and Drug Resistance
Subjects:	Leishmania donovani Visceral leishmaniasis Cyclic nitrofurans Trypanothione Trypanothione reductase Molecular docking
Online Access:	http://www.sciencedirect.com/science/article/pii/S2211320725000284
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Drug-like molecules with anti-trypanothione synthetase activity identified by high throughput screening
by: Diego Benítez, et al.
Published: (2022-12-01)

Expanding the molecular landscape of fragments binding to trypanothione reductase, a legitimate target for drug design against human African trypanosomiasis
by: Cécile Exertier, et al.
Published: (2025-05-01)

Detection of <i>Leishmania donovani</i> DNA from Oral Swab in Visceral Leishmaniasis
by: Santana R. Sarkar, et al.
Published: (2025-02-01)

Dogs as Reservoirs for Leishmania donovani, Bihar, India, 2018–2022
by: Anurag Kumar Kushwaha, et al.
Published: (2024-12-01)

Nitrofurans for External Use (Review)
by: A. V. Beliatskaya, et al.
Published: (2019-05-01)

Nationwide cross-sectional surveillance of Leishmania donovani in phlebotomine sand flies and its impact on national kala-azar elimination in India
by: Harish Kumar Shah, et al.
Published: (2024-11-01)

A comprehensive review on the pretreatment and detection methods of nitrofurans and their metabolites in animal-derived food and environmental samples
by: Xiaoling Zheng, et al.
Published: (2024-12-01)

Estimation of antiparasitic activity of fungal extracts towards Leishmania donovani in murine model
by: Aseel Al-Musa, et al.
Published: (2024-09-01)

ABILITY OF Leishmania donovani TO CONGENITAL TRANSMISSION IN EXPERIMENTAL BALB/C MICE
Published: (2019-06-01)

Antileishmanial Evaluation and Phytochemical Screening of Iraqi Sanchezia speciosa Petroleum Ether Fraction in vitro
by: Muntadher Salim Rasool, et al.
Published: (2025-03-01)

Combination of Cpb-Hsp70 typing methods reveals genetic divergence between Leishmania infantum strains causing human tegumentary leishmaniasis in northern Italy and central Spain: a retrospective study
by: Tommaso Gritti, et al.
Published: (2025-05-01)

Antiprotozoal Natural Products from Endophytic Fungi Associated with Cacao and Coffee
by: Cristopher A. Boya P., et al.
Published: (2024-10-01)

Cutaneous Leishmaniasis: Revisited
by: Saraswoti Neupane
Published: (2018-03-01)

Cutaneous Leishmaniasis: Revisited
by: Saraswoti Neupane
Published: (2018-03-01)

Comprehensive assessment of nitrofurans for lower urinary tract infections
by: Kozlov R.S., et al.
Published: (2025-03-01)

Diagnostic of visceral leishmaniasis by polymerase chain reaction PCR in experimental mice infected which treatment with Viscum album extract and Pentostam.
by: Maksood A.M. Al-Doori, et al.
Published: (2023-02-01)

Molecular Prevalence of <i>Leishmania infantum</i> Infection from Oral Swabs Collected from Dogs in Region of Northwestern Spain
by: Javier Merino-Goyenechea, et al.
Published: (2025-06-01)

In Vitro Leishmanicidal Effect of Silibinin: Disrupting Redox Balance via Trypanothione Reductase Inhibition
by: Natalia Debize da Motta, et al.
Published: (2025-06-01)

Visceral leishmaniasis: Recent updates
by: Jaya Chakravarty, et al.
Published: (2025-06-01)

Leishmaniasis mucocutánea verrucosa: una manifestación inusual
by: Paula Alexandra Mejía, et al.
Published: (2019-02-01)

Exploring Schiff Bases as Promising Alternatives to Traditional Drugs in the In Silico Treatment of Anti-Leishmaniasis as Trypanothione Reductase Inhibitors
by: Diego R. Peixoto, et al.
Published: (2024-11-01)

Exploration of novel azole-quinoline hybrids as LdNMT inhibitors using in-silico approach; molecular docking, DFT, molecular dynamics simulations, MMGBSA and ADMET
by: Firoj Hassan, et al.
Published: (2025-05-01)

Effect of Leishmania proteins in mice: Investigation of Leishmania amazonensis virulence molecules for therapy and prophylaxis of leishmaniasis
by: Cintia Figueiredo de Araújo, et al.
Published: (2025-03-01)

A Systematic Assessment of <i>Leishmania donovani</i> Infection in Domestic and Wild Animal Reservoir Hosts of Zoonotic Visceral Leishmaniasis in India
by: Gajala Deethamvali Ghouse Peer, et al.
Published: (2024-08-01)

Cutaneous leishmaniasis at Wasit governorate
by: Baghdad Science Journal
Published: (2011-06-01)

Prevalence of asymptomatic Leishmania donovani infection and associated factors in Ethiopia: a systematic review and meta-analysis
by: Habtamu Belay, et al.
Published: (2025-01-01)

Healing and leishmanicidal activity of Zanthoxylum rhoifolium Lam.
by: Juliana Correa-Barbosa, et al.
Published: (2025-04-01)

Aster peduncularis Wall. Ex. Nees: in-vitro antibacterial and antileishmanial activities of essential oil from India
by: Bhawana Pant, et al.
Published: (2025-07-01)

A rare case of lingual mucosal leishmaniasis caused by reactivation of Leishmania infantum infection
by: Yannik Eggers, et al.
Published: (2025-02-01)

A Retrospective Study of Cutaneous and Visceral Leishmaniasis in Istanbul, Turkey
by: Serhat Sirekbasan, et al.
Published: (2021-04-01)

THE STUDY OF LEISHMANIASIS USING THE METHOD OF POLYMERASE CHAIN REACTION
by: E. N. Zhirenkina
Published: (2012-03-01)

Sexual and vertical transmission of visceral leishmaniasis
by: Andreia P Turchetti, et al.
Published: (2014-04-01)

CRYOPRESERVATION OF LEISHMANIA DONOVANI PROMASTIGOTES AT -80°C
by: E. Kaneva
Published: (2022-12-01)

Animal reservoirs for visceral leishmaniasis in densely populated urban areas
by: Soraia A. Diniz, et al.
Published: (2008-02-01)

Recombinant Leishmania-activated C kinase as a novel antigenic candidate for immuno-diagnosis of visceral leishmaniasis occurring in India and Brazil
by: Anirban Bhattacharyya, et al.
Published: (2025-07-01)

Scrutinized lipid utilization disrupts Amphotericin-B responsiveness in clinical isolates of Leishmania donovani
by: Supratim Pradhan, et al.
Published: (2025-05-01)

Biochemical and structural characterization of tyrosine aminotransferase suggests broad substrate specificity and a two‐state folding mechanism in Leishmania donovani
by: Santanu Sasidharan, et al.
Published: (2019-10-01)

Immunogenicity and potential protection of DNA vaccine of Leishmania martiniquensis against Leishmania infection in mice
by: Thuntawat Aunguldee, et al.
Published: (2021-09-01)

Development of a novel ddPCR assay for the simultaneous detection of the protozoan parasites Leishmania infantum and Leishmania tarentolae
by: Alessandro Alvaro, et al.
Published: (2025-07-01)

The prevalence of Leishmania RNA virus in cutaneous leishmaniasis: a meta-analysis and systematic review
by: Narjes Yektaeian, et al.
Published: (2025-08-01)