Mechanistic, in-silico and in vitro studies with nitrofurans reveal potent leishmanicidal activity and inhibition of trypanothione reductase

Mechanistic, in-silico and in vitro studies with nitrofurans reveal potent leishmanicidal activity and inhibition of trypanothione reductase

Visceral leishmaniasis caused by Leishmania infantum and Leishmania donovani is one of the neglected tropical diseases (NTDs) caused by trypanosomatids with treatment options limited to outdated drugs often causing adverse effects and promoting drug resistance. Previous antileishmanial drug discover...

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Bibliographic Details
Main Authors: Julia Andrés-Rodríguez, María-Cristina González-Montero, Nerea García-Fernández, Juan-José Galano-Frutos, Maria-Cristina de Rosa, Patricia Ferreira, María-Yolanda Pérez-Pertejo, Rosa M. Reguera, Rafael Balaña-Fouce, Carlos García-Estrada
Format: Article
Language:English
Published: Elsevier 2025-08-01
Series:International Journal for Parasitology: Drugs and Drug Resistance
Subjects:
Leishmania donovani
Visceral leishmaniasis
Cyclic nitrofurans
Trypanothione
Trypanothione reductase
Molecular docking
Online Access:http://www.sciencedirect.com/science/article/pii/S2211320725000284
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