Identification of a multiple DAMP scavenger mimicking the DAMP-binding site of TLR4 to ameliorate lethal sepsis

Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. Current treatments are limited to source control and supportive care, underscoring the urgent need for novel therapeutic interventions. Endogenous molecules released from stressed or damaged cells, kn...

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Bibliographic Details
Main Authors: Takuya Murao, Gaifeng Ma, Atsushi Murao, Alok Jha, Jingsong Li, Yongchan Lee, Mian Zhou, Ping Wang, Monowar Aziz
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Immunology
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Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1540908/full
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