Plant-related quality attributes affecting FcγRIIIa binding: affinity chromatography analysis of rituximab glycovariants from Nicotiana benthamiana

Plant-related quality attributes affecting FcγRIIIa binding: affinity chromatography analysis of rituximab glycovariants from Nicotiana benthamiana

Monoclonal antibodies (mAb) produced in plants, known as plantibodies, represent a cost-effective alternative to conventional mammalian cell cultures. Glycoengineering processes are needed to alter N-glycosylation, avoiding plant-typical glycans and enabling, for anti-cancer mAbs, the production of...

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Bibliographic Details
Main Authors: Sara Tengattini, Aurora Tini, Carla Marusic, Francesca Rinaldi, Isabella Senini, Enrica Calleri, Virginia Perez, Claudio Pisano, Marcello Donini, Caterina Temporini
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Plant Science
Subjects:
plantibodies
monoclonal antibodies
rituximab
glycosylation
glycoengineering
FCγRIIIa receptor
Online Access:https://www.frontiersin.org/articles/10.3389/fpls.2025.1607403/full
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https://www.frontiersin.org/articles/10.3389/fpls.2025.1607403/full

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