Selective EPAC1 activators enhance endothelial function in models of vascular inflammation

Selective EPAC1 activators enhance endothelial function in models of vascular inflammation

Vascular inflammation drives the progression of atherosclerosis and related cardiovascular disorders by impairing endothelial function. Here, we examine the role of EPAC1 - a cAMP-responsive sensor protein - in modulating vascular inflammation and injury using both in vitro and ex vivo models. Data...

Full description

Saved in:
Bibliographic Details
Main Authors: Neil MacRitchie, Danila Gurgone, Jolanta Wiejak, Graeme Barker, Paul Burgoyne, Frank Lezoualc’h, Pasquale Maffia, Stephen J. Yarwood
Format: Article
Language:English
Published: Elsevier 2025-10-01
Series:Pharmacological Research
Subjects:
Aortic Ring Assay
Vascular Inflammation
EPAC1
Non-Cyclic Nucleotide Activators
IL-6 Signalling
Endothelial Nitric Oxide Synthase (eNOS)
Online Access:http://www.sciencedirect.com/science/article/pii/S1043661825003482
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

http://www.sciencedirect.com/science/article/pii/S1043661825003482

Similar Items