Deciphering anti-colorectal cancer potential of Avicennia alba bioactives via network pharmacology and in vitro validation

Deciphering anti-colorectal cancer potential of Avicennia alba bioactives via network pharmacology and in vitro validation

Abstract Colorectal cancer (CRC) remains a significant global health challenge, with the current therapies often being inadequate. This study investigates the potential of Avicennia alba (A. alba), a mangrove plant, as a source of new anticancer drug candidates. We employed a network pharmacology, b...

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Main Authors: Lalu Muhammad Irham, Wirawan Adikusuma, Didi Nurhadi Illian, Maulida Mazaya, Alfian Mubaraq, Muhammad Ma’ruf, Novi Kurnia Rizki, Maya Sari Mutia, Hayssam M. Ali, Mohammad Basyuni
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Avicennia alba
Colorectal cancer
Genomic
Transcriptomic
Docking
Molecular dynamics simulation
Online Access:https://doi.org/10.1038/s41598-025-12500-x
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https://doi.org/10.1038/s41598-025-12500-x

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