DNA Sequence Changes Resulting from Codon Optimization Affect Gene Expression in <i>Pichia pastoris</i> by Altering Chromatin Accessibility

DNA Sequence Changes Resulting from Codon Optimization Affect Gene Expression in <i>Pichia pastoris</i> by Altering Chromatin Accessibility

Codon optimization is a widely employed strategy to enhance protein expression. However, it occasionally leads to unexpected transcriptional repression despite preserving amino acid sequences. This study investigates the mechanistic basis of such transcriptional attenuation by analyzing two gene can...

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Bibliographic Details
Main Authors: Chaoyu Lu, Linna Guo, Bohao Fang, Jiacheng Shi, Mian Zhou
Format: Article
Language:English
Published: MDPI AG 2025-04-01
Series:Journal of Fungi
Subjects:
codon usage bias
nucleosome occupancy
chromatin accessibility
<i>Pichia pastoris</i>
Online Access:https://www.mdpi.com/2309-608X/11/4/282
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