CTB alleviated premature ovarian insufficiency induced by cigarette smoke exposure in mice through activating CREB1 by P300-mediated histone acetylation modifications

CTB alleviated premature ovarian insufficiency induced by cigarette smoke exposure in mice through activating CREB1 by P300-mediated histone acetylation modifications

Our previous research indicated that exposure to cigarette smoke (CS) can lead to premature ovarian insufficiency (POI) in mice, primarily through oxidative stress and an imbalance between cell proliferation and apoptosis in ovarian granulosa cells (GCs), which is linked to the downregulation of GPX...

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Bibliographic Details
Main Authors: Nengyin Hu, Na Xin, Ying Wang, Dongyan Liu, Yanhui Zhao, Mengting Xu, Fang Li, Jianing Miao, Sailing Ji, Lili Wang
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:Ecotoxicology and Environmental Safety
Subjects:
Cigarette smoke exposure
Primary ovarian insufficiency
CTB
P300
CREB1
Histone acetylation modification
Online Access:http://www.sciencedirect.com/science/article/pii/S0147651325009704
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