Host-Mediated Antimicrobial Effects and NLRP3 Inflammasome Modulation by Caulerpin and Its Derivatives in Macrophage Models of Mycobacterial Infections

Host-Mediated Antimicrobial Effects and NLRP3 Inflammasome Modulation by Caulerpin and Its Derivatives in Macrophage Models of Mycobacterial Infections

Caulerpin, a bis-indole alkaloid isolated from <i>Caulerpa racemosa</i>, has several documented pharmacological activities, including antineoplastic and antiviral properties. This study aimed to evaluate the anti-inflammatory and anti-tubercular potentials of caulerpin and its analogues...

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Main Authors: Maria Gabriella S. Sidrônio, Maria Eugênia G. Freitas, Daniel W. A. Magalhães, Deyse C. M. Carvalho, Vinícius A. B. Gonçalves, Ana Caroline M. de Queiroz Oliveira, Gisela C. Paulino, Gabriela C. Borges, Rafaelle L. Ribeiro, Natália Ferreira de Sousa, Marcus T. Scotti, Demétrius A. M. de Araújo, Francisco Jaime B. Mendonça-Junior, Kristerson R. de Luna Freire, Sandra Rodrigues-Mascarenhas, Bárbara Viviana de O. Santos, Valnês S. Rodrigues-Junior
Format: Article
Language:English
Published: MDPI AG 2025-03-01
Series:Microorganisms
Subjects:
tuberculosis
drug development
caulerpin
host-directed therapy
toxicity
anti-inflammatory
Online Access:https://www.mdpi.com/2076-2607/13/3/561
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