Activation of the cGAS‐STING‐IRF3 Axis by Type I and II Interferons Contributes to Host Defense

Activation of the cGAS‐STING‐IRF3 Axis by Type I and II Interferons Contributes to Host Defense

Abstract Interferons (IFNs) activate JAK‐STAT pathways to induce downstream effector genes for host defense against invaded pathogens and tumors. Here both type I (β) and II (γ) IFNs are shown that can activate the transcription factor IRF3 in parallel with STAT1. IRF3‐deficiency impairs transcripti...

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Bibliographic Details
Main Authors: Zhen Tong, Jia‐Peng Zou, Su‐Yun Wang, Wei‐Wei Luo, Yan‐Yi Wang
Format: Article
Language:English
Published: Wiley 2024-09-01
Series:Advanced Science
Subjects:
antitumor
antiviral responses
cGAS‐STING‐IRF3
interferon
JAK‐STATs
phosphorylation
Online Access:https://doi.org/10.1002/advs.202308890
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https://doi.org/10.1002/advs.202308890

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