Phosphodiesterase 7: a potential novel therapeutic target in ovarian cancer

Phosphodiesterase 7: a potential novel therapeutic target in ovarian cancer

IntroductionChemoresistance and disease relapses in epithelial ovarian cancer (EOC) highlight the need for novel therapeutic strategies. Here, we investigated phosphodiesterase 7A (PDE7A) as a potential target in ovarian cancer treatment.MethodsGene expression was performed by RNA sequencing data co...

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Main Authors: Nayara Gusmão Tessarollo, Isabella dos Santos Guimarães, Diandra Zipinotti dos Santos, Taciane Barbosa Henriques, Paulo Cilas Morais Lyra-Junior, Josiany Carlos de Souza, Tatiana Massariol Pimenta, Bárbara da Silva Martins, Solenny Maria Silva Butzene, José Matheus Simões Padilha, Leide Laura Figueiredo Maciel, João Carlos de Aquino Almeida, Ian Victor Silva, Leticia Batista Azevedo Rangel
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Pharmacology
Subjects:
ovarian cancer
phosphodiesterase 7-A
PI3K/AKT/mTOR signaling pathway modulation
paclitaxel
mitochondrial cristae morphology alteration
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1566330/full
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https://www.frontiersin.org/articles/10.3389/fphar.2025.1566330/full

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