Cutaneous Polyarteritis Nodosa Presenting Atypically with Severe Pharyngeal Ulceration
Polyarteritis nodosa (PAN) is a multisystem, necrotising vasculitis of small- and medium-sized arteries with a predilection for the visceral vessels. Cutaneous PAN is a rare variant with symptomatic vasculitis limited to the skin, typically presenting as nodular lesions on the extremities with a pro...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Case Reports in Rheumatology |
| Online Access: | http://dx.doi.org/10.1155/2019/2631948 |
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| author | Bayanne Olabi Justin C. Mason Ziad Farah |
| author_facet | Bayanne Olabi Justin C. Mason Ziad Farah |
| author_sort | Bayanne Olabi |
| collection | DOAJ |
| description | Polyarteritis nodosa (PAN) is a multisystem, necrotising vasculitis of small- and medium-sized arteries with a predilection for the visceral vessels. Cutaneous PAN is a rare variant with symptomatic vasculitis limited to the skin, typically presenting as nodular lesions on the extremities with a propensity to ulcerate. We describe a rare case of histologically confirmed cutaneous PAN presenting in a 55-year-old Ghanaian woman with severe oropharyngeal ulceration. This was associated with dysphagia and significant weight loss. Oesophagoduodenoscopy showed that the ulceration extended throughout the oropharynx. Systemic polyarteritis nodosa was ruled out with magnetic resonance angiography. Our patient was treated successfully with corticosteroids and methotrexate. This case suggests that cutaneous PAN should be considered in the differential diagnosis of patients with oropharyngeal ulceration and that histological assessment is pivotal in establishing the diagnosis early in order to instigate appropriate therapy. |
| format | Article |
| id | doaj-art-5900b1a0b42b4ed69fd4b5f100579f3e |
| institution | Kabale University |
| issn | 2090-6889 2090-6897 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Rheumatology |
| spelling | doaj-art-5900b1a0b42b4ed69fd4b5f100579f3e2025-02-03T01:06:54ZengWileyCase Reports in Rheumatology2090-68892090-68972019-01-01201910.1155/2019/26319482631948Cutaneous Polyarteritis Nodosa Presenting Atypically with Severe Pharyngeal UlcerationBayanne Olabi0Justin C. Mason1Ziad Farah2NHS Lothian, Department of Dermatology, Lauriston Building, Lauriston Place, Edinburgh EH3 9EN, UKRheumatology Section, Imperial College Healthcare NHS Trust, Hammersmith Hospital, Du Cane Road, London W12 0HS, UKRheumatology Section, Imperial College Healthcare NHS Trust, Hammersmith Hospital, Du Cane Road, London W12 0HS, UKPolyarteritis nodosa (PAN) is a multisystem, necrotising vasculitis of small- and medium-sized arteries with a predilection for the visceral vessels. Cutaneous PAN is a rare variant with symptomatic vasculitis limited to the skin, typically presenting as nodular lesions on the extremities with a propensity to ulcerate. We describe a rare case of histologically confirmed cutaneous PAN presenting in a 55-year-old Ghanaian woman with severe oropharyngeal ulceration. This was associated with dysphagia and significant weight loss. Oesophagoduodenoscopy showed that the ulceration extended throughout the oropharynx. Systemic polyarteritis nodosa was ruled out with magnetic resonance angiography. Our patient was treated successfully with corticosteroids and methotrexate. This case suggests that cutaneous PAN should be considered in the differential diagnosis of patients with oropharyngeal ulceration and that histological assessment is pivotal in establishing the diagnosis early in order to instigate appropriate therapy.http://dx.doi.org/10.1155/2019/2631948 |
| spellingShingle | Bayanne Olabi Justin C. Mason Ziad Farah Cutaneous Polyarteritis Nodosa Presenting Atypically with Severe Pharyngeal Ulceration Case Reports in Rheumatology |
| title | Cutaneous Polyarteritis Nodosa Presenting Atypically with Severe Pharyngeal Ulceration |
| title_full | Cutaneous Polyarteritis Nodosa Presenting Atypically with Severe Pharyngeal Ulceration |
| title_fullStr | Cutaneous Polyarteritis Nodosa Presenting Atypically with Severe Pharyngeal Ulceration |
| title_full_unstemmed | Cutaneous Polyarteritis Nodosa Presenting Atypically with Severe Pharyngeal Ulceration |
| title_short | Cutaneous Polyarteritis Nodosa Presenting Atypically with Severe Pharyngeal Ulceration |
| title_sort | cutaneous polyarteritis nodosa presenting atypically with severe pharyngeal ulceration |
| url | http://dx.doi.org/10.1155/2019/2631948 |
| work_keys_str_mv | AT bayanneolabi cutaneouspolyarteritisnodosapresentingatypicallywithseverepharyngealulceration AT justincmason cutaneouspolyarteritisnodosapresentingatypicallywithseverepharyngealulceration AT ziadfarah cutaneouspolyarteritisnodosapresentingatypicallywithseverepharyngealulceration |