TET1 functions as a tumor suppressor in lung adenocarcinoma through epigenetic remodeling and immune modulation

TET1 functions as a tumor suppressor in lung adenocarcinoma through epigenetic remodeling and immune modulation

Abstract Background Ten-Eleven Translocation (TET1-3) dioxygenases oxidize 5-methylcytosine (5mC) in DNA to generate 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC), and 5-carboxylcytosine (5caC), initiating DNA demethylation. Since their discovery in 2009, there have been contradictory repor...

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Bibliographic Details
Main Authors: Abdur Rahim, Brian L. Ruis, Andrew T. Rajczewski, Monica E. Kruk, Natalia Y. Tretyakova
Format: Article
Language:English
Published: BMC 2025-08-01
Series:Epigenetics & Chromatin
Subjects:
TET1 protein
DNA methylation
Lung cancer
Tumor suppressor gene
3D spheroid
Online Access:https://doi.org/10.1186/s13072-025-00617-2
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https://doi.org/10.1186/s13072-025-00617-2

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