JC Polyomavirus Abundance and Distribution in Progressive Multifocal Leukoencephalopathy (PML) Brain Tissue Implicates Myelin Sheath in Intracerebral Dissemination of Infection.

JC Polyomavirus Abundance and Distribution in Progressive Multifocal Leukoencephalopathy (PML) Brain Tissue Implicates Myelin Sheath in Intracerebral Dissemination of Infection.

Over half of adults are seropositive for JC polyomavirus (JCV), but rare individuals develop progressive multifocal leukoencephalopathy (PML), a demyelinating JCV infection of the central nervous system. Previously, PML was primarily seen in immunosuppressed patients with AIDS or certain cancers, bu...

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Main Authors: Keith A Wharton, Catherine Quigley, Marian Themeles, Robert W Dunstan, Kathryn Doyle, Ellen Cahir-McFarland, Jing Wei, Alex Buko, Carl E Reid, Chao Sun, Paul Carmillo, Gargi Sur, John P Carulli, Keith G Mansfield, Susan V Westmoreland, Susan M Staugaitis, Robert J Fox, Werner Meier, Susan E Goelz
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0155897&type=printable
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https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0155897&type=printable

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