Salivary shield: Rhodnius prolixus salivary glandular extract reduces intestinal immunopathology and protects against Toxoplasma gondii infection

Salivary shield: Rhodnius prolixus salivary glandular extract reduces intestinal immunopathology and protects against Toxoplasma gondii infection

Abstract C57BL/6 mice, orally infected with T. gondii, experience pronounced severe intestinal inflammation, causing necrosis, weight loss, and bacterial translocation. In addition, immunomodulatory molecules such as lipocalins, nitrophorins, and apyrases are present in R. prolixus saliva. Our objec...

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Main Authors: Roberto Augusto Pereira Sousa, Jean Henrique Nunes de Paula, Rafaela José Silva, Samuel Cota Teixeira, Flávia Batista Ferreira França, Amanda Helena Leão Gonçalves, Túlio Rodrigues Oliveira Silva, Maria Julia Granero-Rosa, Murilo Vieira Silva, Marcos de Lucca Moreira Gomes, Marcos Vinícius Silva, Virmondes Rodrigues Junior, José Roberto Mineo, Bellisa Freitas Barbosa, Eloisa Amália Vieira Ferro, Carlo José Freire Oliveira, Angelica Oliveira Gomes
Format: Article
Language:English
Published: BMC 2025-03-01
Series:Gut Pathogens
Subjects:
Triatomines
Saliva
Rhodnius prolixus
Inflammatory bowel diseases
Toxoplasma gondii
Cytokines
Online Access:https://doi.org/10.1186/s13099-024-00676-y
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https://doi.org/10.1186/s13099-024-00676-y

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