Injuries in Left Corticospinal Tracts, Forceps Major, and Left Superior Longitudinal Fasciculus (Temporal) as the Quality Indicators for Major Depressive Disorder
At present, the etiology and pathogenesis of major depressive disorder (MDD) are still not clear. Studies have found that the risk of first-degree relatives of MDD is 2–3 times that of the general population. Diffusion tensor imaging (DTI) has been previously used to explore the pathogenesis of MDD....
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| Format: | Article |
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Wiley
2021-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2021/2348072 |
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| author | Ziwei Liu Lijun Kang Aixia Zhang Chunxia Yang Min Liu Jizhi Wang Penghong Liu Kerang Zhang Ning Sun |
| author_facet | Ziwei Liu Lijun Kang Aixia Zhang Chunxia Yang Min Liu Jizhi Wang Penghong Liu Kerang Zhang Ning Sun |
| author_sort | Ziwei Liu |
| collection | DOAJ |
| description | At present, the etiology and pathogenesis of major depressive disorder (MDD) are still not clear. Studies have found that the risk of first-degree relatives of MDD is 2–3 times that of the general population. Diffusion tensor imaging (DTI) has been previously used to explore the pathogenesis of MDD. The purpose of this study is to explore the etiology of MDD by DTI and further to explore the correlation between its clinical characteristics and the structural changes of white matter in the brain. The study included 27 first-episode, drug-naive patients with MDD, 16 first-degree relatives without MDD, and 28 healthy control subjects with no family history of MDD (HC). Results showed that the fractional anisotropy (FA) differences among the three groups were mainly in the left anterior thalamic radiation (LATR), right anterior thalamic radiation (RATR), left corticospinal tracts (LCST), forceps major (FMa), right inferior longitudinal fasciculus (RILF), and left superior longitudinal fasciculus (temporal) (LSLF(T)). Among the 6 sites, LCST, FMa, and LSLF(T) showed significant differences between MDD and First-degree relatives compared to HC. MDD patients had significant emotional symptoms, somatic symptoms, and cognitive impairment. FMa FA was significantly positively correlated with delayed memory score (r=0.43, P=0.031), and RILF FA was significantly negatively correlated with the FSS score (r=−0.42, P=0.028). These results revealed that the white matter characteristics of MDD-susceptible patients were LCST, FMa, and LSLF(T) lesions, all of which may be quality indicators of MDD. |
| format | Article |
| id | doaj-art-58da82021cbb4a6183005e4b6c0e3ebb |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-58da82021cbb4a6183005e4b6c0e3ebb2025-02-03T01:08:48ZengWileyNeural Plasticity2090-59041687-54432021-01-01202110.1155/2021/23480722348072Injuries in Left Corticospinal Tracts, Forceps Major, and Left Superior Longitudinal Fasciculus (Temporal) as the Quality Indicators for Major Depressive DisorderZiwei Liu0Lijun Kang1Aixia Zhang2Chunxia Yang3Min Liu4Jizhi Wang5Penghong Liu6Kerang Zhang7Ning Sun8Department of Psychiatry, First Hospital of Shanxi Medical University, Taiyuan, ChinaDepartment of Psychiatry, First Hospital of Shanxi Medical University, Taiyuan, ChinaDepartment of Psychiatry, First Hospital of Shanxi Medical University, Taiyuan, ChinaDepartment of Psychiatry, First Hospital of Shanxi Medical University, Taiyuan, ChinaDepartment of Psychiatry, First Hospital of Shanxi Medical University, Taiyuan, ChinaDepartment of Psychiatry, First Hospital of Shanxi Medical University, Taiyuan, ChinaDepartment of Psychiatry, First Hospital of Shanxi Medical University, Taiyuan, ChinaDepartment of Psychiatry, First Hospital of Shanxi Medical University, Taiyuan, ChinaDepartment of Psychiatry, First Hospital of Shanxi Medical University, Taiyuan, ChinaAt present, the etiology and pathogenesis of major depressive disorder (MDD) are still not clear. Studies have found that the risk of first-degree relatives of MDD is 2–3 times that of the general population. Diffusion tensor imaging (DTI) has been previously used to explore the pathogenesis of MDD. The purpose of this study is to explore the etiology of MDD by DTI and further to explore the correlation between its clinical characteristics and the structural changes of white matter in the brain. The study included 27 first-episode, drug-naive patients with MDD, 16 first-degree relatives without MDD, and 28 healthy control subjects with no family history of MDD (HC). Results showed that the fractional anisotropy (FA) differences among the three groups were mainly in the left anterior thalamic radiation (LATR), right anterior thalamic radiation (RATR), left corticospinal tracts (LCST), forceps major (FMa), right inferior longitudinal fasciculus (RILF), and left superior longitudinal fasciculus (temporal) (LSLF(T)). Among the 6 sites, LCST, FMa, and LSLF(T) showed significant differences between MDD and First-degree relatives compared to HC. MDD patients had significant emotional symptoms, somatic symptoms, and cognitive impairment. FMa FA was significantly positively correlated with delayed memory score (r=0.43, P=0.031), and RILF FA was significantly negatively correlated with the FSS score (r=−0.42, P=0.028). These results revealed that the white matter characteristics of MDD-susceptible patients were LCST, FMa, and LSLF(T) lesions, all of which may be quality indicators of MDD.http://dx.doi.org/10.1155/2021/2348072 |
| spellingShingle | Ziwei Liu Lijun Kang Aixia Zhang Chunxia Yang Min Liu Jizhi Wang Penghong Liu Kerang Zhang Ning Sun Injuries in Left Corticospinal Tracts, Forceps Major, and Left Superior Longitudinal Fasciculus (Temporal) as the Quality Indicators for Major Depressive Disorder Neural Plasticity |
| title | Injuries in Left Corticospinal Tracts, Forceps Major, and Left Superior Longitudinal Fasciculus (Temporal) as the Quality Indicators for Major Depressive Disorder |
| title_full | Injuries in Left Corticospinal Tracts, Forceps Major, and Left Superior Longitudinal Fasciculus (Temporal) as the Quality Indicators for Major Depressive Disorder |
| title_fullStr | Injuries in Left Corticospinal Tracts, Forceps Major, and Left Superior Longitudinal Fasciculus (Temporal) as the Quality Indicators for Major Depressive Disorder |
| title_full_unstemmed | Injuries in Left Corticospinal Tracts, Forceps Major, and Left Superior Longitudinal Fasciculus (Temporal) as the Quality Indicators for Major Depressive Disorder |
| title_short | Injuries in Left Corticospinal Tracts, Forceps Major, and Left Superior Longitudinal Fasciculus (Temporal) as the Quality Indicators for Major Depressive Disorder |
| title_sort | injuries in left corticospinal tracts forceps major and left superior longitudinal fasciculus temporal as the quality indicators for major depressive disorder |
| url | http://dx.doi.org/10.1155/2021/2348072 |
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