Post-stroke butyrate treatment shows sex-dependent microglial responses but does not improve outcomes in a mouse model of endothelin-1 sensory motor stroke

Post-stroke butyrate treatment shows sex-dependent microglial responses but does not improve outcomes in a mouse model of endothelin-1 sensory motor stroke

Abstract Background Stroke induces gut dysbiosis and reduces microbial production of short-chain carboxylic acids (SCCAs), which negatively correlates with stroke outcomes. Previous studies have demonstrated that SCCA supplementation can improve functional recovery, with one recent study suggesting...

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Main Authors: Ashley de Witte, Juliana Montoya Sanchez, Emerson Daniele, Jingan Chen, Yibang Fan, Pranav Khatri, Daniela Lozano Casasbuenas, Angel Zhang, Kathryn G. Todd, Maryam Faiz, Matthew Churchward
Format: Article
Language:English
Published: BMC 2025-07-01
Series:BMC Neuroscience
Subjects:
Butyrate
Short-chain carboxylic acids (SCCAs)
Sex differences
Ischemic stroke
Microglia
Gut-brain axis
Online Access:https://doi.org/10.1186/s12868-025-00959-3
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https://doi.org/10.1186/s12868-025-00959-3

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