Silibinin protects the ischemic brain in mice by exerting anti-apoptotic effects via the EGFR/ERK pathway

Silibinin protects the ischemic brain in mice by exerting anti-apoptotic effects via the EGFR/ERK pathway

Apoptosis is a significant occurrence of cell death in the cerebral ischemia process, potentially revealing specific treatment points. Silibinin (SIL) has been proven to regulate a range of biological effects on inflammation, oxidative stress and apoptosis. Meanwhile, the epidermal growth factor rec...

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Bibliographic Details
Main Authors: Linlin Li, Wenyan Shang, Yuexia Ma, Cong Zhang, Xiangjian Zhang
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Brain Research Bulletin
Subjects:
Ischemic stroke
Silibinin
Apoptosis
EGFR/ERK
C225
Bcl-2
Online Access:http://www.sciencedirect.com/science/article/pii/S0361923025001650
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