Genome-wide DNA methylation analysis identifies kidney epigenetic dysregulation in a cystinosis mouse model

Genome-wide DNA methylation analysis identifies kidney epigenetic dysregulation in a cystinosis mouse model

IntroductionNephropathic cystinosis is a rare genetic disorder characterized by cystine accumulation in lysosomes that causes early renal dysfunction and progressive chronic kidney disease. Although several metabolic pathways, including oxidative stress and inflammation, have been implicated in the...

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Main Authors: M. N. Rossi, A. Ciolfi, V. Matteo, L. Pedace, C. Nardini, E. Loricchio, I. Caiello, F. Bellomo, A. Taranta, E. De Leo, M. Tartaglia, F. Emma, F. De Benedetti, E. Miele, G. Prencipe
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
cystinosis
DNA methylation
solute carrier genes
kidney disease
proximal tubular epithelial cells
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2025.1638123/full
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https://www.frontiersin.org/articles/10.3389/fcell.2025.1638123/full

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