Patient-derived tumoroids from CIC::DUX4 rearranged sarcoma identify MCL1 as a therapeutic target

Patient-derived tumoroids from CIC::DUX4 rearranged sarcoma identify MCL1 as a therapeutic target

Abstract High-risk sarcomas, such as metastatic and relapsed Ewing and CIC-rearranged sarcoma, still have a poor prognosis despite intensive therapeutic regimens. Precision medicine approaches offer hope, and ex vivo drug response profiling of patient-derived tumor cells emerges as a promising tool...

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Main Authors: Willemijn Breunis, Eva Brack, Anna C. Ehlers, Ingrid Bechtold, Samanta Kisele, Jakob Wurth, Lieke Mous, Dorita Zabele, Fabio Steffen, Felina Zahnow, Christian Britschgi, Lorenz Bankel, Christian Rothermundt, Cornelia Vetter, Daniel Müller, Sander Botter, Chantal Pauli, Peter Bode, Beate Rinner, Jean-Pierre Bourquin, Jochen Roessler, Thomas G. P. Grünewald, Beat W. Schäfer, Didier Surdez, Marco Wachtel
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-62629-6
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https://doi.org/10.1038/s41467-025-62629-6

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