Elevated activity of plasma dipeptidyl peptidase 4 upon stress can be targeted to reverse tumor immunosuppression

Elevated activity of plasma dipeptidyl peptidase 4 upon stress can be targeted to reverse tumor immunosuppression

The interplay between stress-induced metabolic reprogramming and perturbations in the cancer-immune dialogue is a challenging research topic with huge knowledge gaps to fill. In a repeated social defeat model, we discovered that circulating corticosterone, blood glucose, and plasma DPP4 activity wer...

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Main Authors: Peipei Li, Menghe Liang, Junlin Zhu, Jian Chen, Lin Xia, Ziqi Jin, Xiao Zhang, Shuqing Zhang, Qi Wang, Zhen Liu, Yu Ping, Zhenxin Wang, Catherine CL Wong, Yi Zhang, Heng Yang, Zilu Ye, Yuting Ma
Format: Article
Language:English
Published: Elsevier 2025-05-01
Series:Pharmacological Research
Subjects:
Stress
DPP4
Tumor
Immune response
Proteome
Online Access:http://www.sciencedirect.com/science/article/pii/S1043661825001215
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