Effects and mechanisms of trifolin on attenuating hypertension-induced vascular smooth muscle cell proliferation and collagen deposition in vivo and in vitro

Effects and mechanisms of trifolin on attenuating hypertension-induced vascular smooth muscle cell proliferation and collagen deposition in vivo and in vitro

Abstract Trifolin exhibits anti-tumor activities; however, its effect on hypertension remains unknown. This study was performed to investigate trifolin’s potential therapeutic effects and underlying mechanisms of action on angiotensin II (Ang II)-induced hypertension in mice and Ang II stimulated A7...

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Bibliographic Details
Main Authors: Aling Shen, Meizhu Wu, Zhi Guo, Farman Ali, Jinkong Wu, Hong Chen, Ying Cheng, Dawei Lian, Jun Peng, Min Yu, Keji Chen
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Scientific Reports
Subjects:
Hypertension
Networking pharmacology
Trifolin
Vascular smooth muscle cells
PI3K/AKT
Online Access:https://doi.org/10.1038/s41598-025-01022-1
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https://doi.org/10.1038/s41598-025-01022-1

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