Rapid intravenous symptom-inhibiting fentanyl induction (SIFI) to optimize rotation onto oral opioid agonist therapy among individuals who use unregulated fentanyl: protocol for an open-label, single arm clinical trial

Rapid intravenous symptom-inhibiting fentanyl induction (SIFI) to optimize rotation onto oral opioid agonist therapy among individuals who use unregulated fentanyl: protocol for an open-label, single arm clinical trial

Abstract Background Most opioid use disorder (OUD) treatment guidelines target community medical settings, and the subsequent recommendations were established to prioritize safety and reduce diversion prior to the fentanyl era. For people with OUD who use unregulated fentanyl, slow induction onto op...

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Main Authors: Pouya Azar, Martha J. Ignaszewski, Marianne Harris, Zoran Barazanci, Ruth Davison, James S. H. Wong, Anil Maharaj, Nickie Mathew, David Hall, Silvia A. Guillemi, Julie Foreman, Rolando Barrios, Julio S. G. Montaner
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Addiction Science & Clinical Practice
Subjects:
Fentanyl
Methadone
Opioid use disorder
Opioid substitution treatment
Online Access:https://doi.org/10.1186/s13722-025-00586-7
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https://doi.org/10.1186/s13722-025-00586-7

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