A proteomic and functional view of intrabacterial lipid inclusion biogenesis in mycobacteria

A proteomic and functional view of intrabacterial lipid inclusion biogenesis in mycobacteria

ABSTRACT During infection and granuloma formation, pathogenic mycobacteria store triacylglycerol as intrabacterial lipid inclusions (ILIs). This accumulation of nutrients provides a carbon source for bacterial persistence and slows down intracellular metabolism. Mycobacterium abscessus (Mab), a rapi...

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Main Authors: Tonia Dargham, John Jairo Aguilera-Correa, Romain Avellan, Ivy Mallick, Léa Celik, Pierre Santucci, Gael Brasseur, Isabelle Poncin, Vanessa Point, Stéphane Audebert, Luc Camoin, Wassim Daher, Jean-François Cavalier, Laurent Kremer, Stéphane Canaan
Format: Article
Language:English
Published: American Society for Microbiology 2025-04-01
Series:mBio
Subjects:
Intracellular lipid inclusion
lipid metabolism
persistence
Mycobacterium abscessus
ILI-associated proteins
proteomic
Online Access:https://journals.asm.org/doi/10.1128/mbio.01475-24
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https://journals.asm.org/doi/10.1128/mbio.01475-24

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