A mouse model of cardiac immunoglobulin light chain amyloidosis reveals insights into tissue accumulation and toxicity of amyloid fibrils

A mouse model of cardiac immunoglobulin light chain amyloidosis reveals insights into tissue accumulation and toxicity of amyloid fibrils

Abstract Immunoglobulin light chain (LC) amyloidosis (AL) is one of the most common types of systemic amyloidosis but there is no reliable in vivo model for better understanding this disease. Here, we develop a transgenic mouse model producing a human AL LC. We show that the soluble full length LC i...

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Main Authors: Gemma Martinez-Rivas, Maria Victoria Ayala, Sebastien Bender, Gilles Roussine Codo, Weronika Karolina Swiderska, Alessio Lampis, Laura Pedroza, Melisa Merdanovic, Pierre Sicard, Emilie Pinault, Laurence Richard, Francesca Lavatelli, Sofia Giorgetti, Diana Canetti, Alexa Rinsant, Sihem Kaaki, Cécile Ory, Christelle Oblet, Justine Pollet, Eyad Naser, Alexander Carpinteiro, Muriel Roussel, Vincent Javaugue, Arnaud Jaccard, Amélie Bonaud, Laurent Delpy, Michael Ehrmann, Frank Bridoux, Christophe Sirac
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-58307-2
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https://doi.org/10.1038/s41467-025-58307-2

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